India defeated Australia by 99 runs in the second One-Day International on September 24 at the Holkar Cricket Stadium in Indore, giving them a commanding 2-0 series lead.

India, who were given the opportunity to bat first, scored 399/5 against Australia in their allotted 50 overs, their best ODI total. While captain KL Rahul (52 off 38) and Suryakumar Yadav (72 off 37) produced superb fifties, Shubman Gill (104 off 97) and Shreyas Iyer (105 off 90) shone with the bat.

Australia suffered a twin blow in the second innings when Prasidh Krishna dismissed Steve Smith (0 off 1) and Matthew Short (9 off 8) in the same over. David Warner (53 off 39), who scored Australia's second successive fifty of the series, did his utmost to keep his team in the match. He did not, however, receive much assistance from others. Australia was eventually knocked out for 217 runs, giving India a 99-run victory.

Brief scores: India 399/5 in 50 overs (Shreyas Iyer 105, Shubman Gill 104, Suryakumar Yadav 72*, KL Rahul 52; Cameron Green 2-103) beat Australia 217 (Sean Abbott 54, David Warner 53; R Ashwin 3-41, Ravindra Jadeja 3-42) by 99 runs (DLS method).