In a World Cup qualifying match on Thursday, Uruguay defeated the world champions 2-0 to snap Argentina's 14-game winning streak.
At the Bombonera Stadium in Buenos Aires, a fierce match was settled when Uruguayan defender Ronald Araujo gave his team the lead on 41 minutes. Darwin Nunez of Liverpool, on the counterattack, then made the game safe with a goal in the 87th minute.
Argentina lost for the first time since they were shocked 2-1 by Saudi Arabia in the 2022 World Cup finals in Qatar. It was also Lionel Messi's team's first setback of the 2026 World Cup qualification campaign.
"We never felt comfortable," Messi said after the defeat.
"They're a physical team that works well and on the counterattack they were very dangerous," added Messi, praising the work of Uruguay's revered Argentine coach Marcelo Bielsa.